School of Sciences and Humanities
School of Sciences and Humanities
School of Sciences and Humanities
Department of Biology
One Health and Biodiversity
The Biology Department has number of scholars interested broadly in themes of One Health and biodiversity who pursue under the C4 BioCluster umbrella research covering:
- biophotonics applied in cell biology, cancer biology, and environmental systems
- molecular basis of human diseases including cancer, infectious diseases, autoimmunity and neurological diseases,
- biotechnology, biosensors, nanoparticle delivery, and bioinformatics
C4 BioCluster Research Thrusts
Laboratory of Molecular Mechanisms of Diseases
Laboratory for Cell Growth Regulation
Dos Sarbassov group
Laboratory of Biochemical Immunology
Representative publications
Laboratory for Cell Growth Regulation
Dos Sarbassov group
Laboratory of Biochemical Immunology
Representative publications
- Nuta O, Rothkamm K, Darroudi F. The Role of Telomerase in Radiation-Induced Genomic Instability. Radiat Res. 2020 Mar 9. doi: 10.1667/RR15495.1.
- Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 May 15;146(10):2822-2828. doi: 10.1002/ijc.32658.
- Schroeder R, Grzywa R, Wirtz CR, Sienczyk M, Burster T. Application of a novel FAM-conjugated activity-based probe to determine cathepsin G activity intracellularly. Anal Biochem. 2020;588:113488. doi:10.1016/j.ab.2019.113488.
- Myngbay A, Bexeitov Y, Adilbayeva A, Assylbekov Z, Yevstratenko BP, Aitzhanova RM, Matkarimov B, Adarichev VA, Kunz J. CTHRC1: A New Candidate Biomarker for Improved Rheumatoid Arthritis Diagnosis. Front Immunol. 2019 Jun 12;10:1353. doi: 10.3389/fimmu.2019.01353.
- Andreeva A, Bekkhozhin Z, Omertassova N, Baizhumanov T, Yeltay G, Akhmetali M, Toibazar D, Utepbergenov D. The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals. J Biol Chem. 2019 Dec 6;294(49):18863-18872, doi: 10.1074/jbc.RA119.011237
- Shevtsova E, Vergnaud G, Shevtsov A, Shustov A, Berdimuratova K, Mukanov K, Syzdykov M, Kuznetsov A, Lukhnova L, Izbanova U, Filipenko M, Ramankulov Y. Genetic Diversity of Brucella melitensis in Kazakhstan in Relation to World-Wide Diversity. Front Microbiol. 2019 Aug 13;10:1897. doi: 10.3389/fmicb.2019.01897.
- Dammann F, Kirschstein T, Guli X, Müller S, Porath K, Rohde M, Tokay T, Köhling R. Bidirectional shift of group III metabotropic glutamate receptor-mediated synaptic depression in the epileptic hippocampus. Epilepsy Res. 2018 Jan;139:157-163. doi: 10.1016/j.eplepsyres.2017.12.002.
Representative publications:
- Veremeyko T, Kuznetsova IS, Dukhinova M, W Y Yung A, Kopeikina E, Barteneva NS, Ponomarev ED. Neuronal extracellular microRNAs miR-124 and miR-9 mediate cell-cell communication between neurons and microglia. J Neurosci Res. 2019;97(2):162‐184. doi:10.1002/jnr.24344
- Pham TT, Monnard A, Helenius J, Lund E, Lee N, Müller DJ, Cabernard C. Spatiotemporally Controlled Myosin Relocalization and Internal Pressure Generate Sibling Cell Size Asymmetry. iScience. 2019 Mar 29;13:9-19. doi: 10.1016/j.isci.2019.02.002.
- Potashnikova DM, Golyshev SA, Penin AA, Logacheva MD, Klepikova AV, Zharikova AA, Mironov AA, Sheval EV, Vorobjev IA. FACS Isolation of Viable Cells in Different Cell Cycle Stages from Asynchronous Culture for RNA Sequencing. Methods Mol Biol. 2018;1745:315-335. doi: 10.1007/978-1-4939-7680-5_18.
- Dashkova V, Clapper J, Vorobjev IA, Barteneva NS. Spectral and Imaging Flow Cytometry in Phytoplankton Research. Methods Mol Biol. 2018;1745:83-95. doi:10.1007/978-1-4939-7680-5_5
- Trifonova RT, Barteneva NS. Quantitation of IRF3 Nuclear Translocation in Heterogeneous Cellular Populations from Cervical Tissue Using Imaging Flow Cytometry. Methods Mol Biol. 2018;1745:125-153.
- Guney M, Yagofarova A, Yapiyev V, Schönbach C, Kim JR, Inglezakis VJ. Distribution of potentially toxic soil elements along a transect across Kazakhstan. Geoderma Regional. 2020; 21, e00281. doi.org/10.1016/j.geodrs.2020.e00281
- Roubinet C, Tsankova A*, Pham TT*, Monnard A, Caussinus E, Affolter M, Cabernard C. Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells. Nat Commun. 2017 Nov 9;8(1):1383. doi: 10.1038/s41467-017-01391-w.*equal contribution
Representative publications
- Sypabekova M, Dukenbayev K, Tsepke A, Akisheva A, Oralbayev N, Kanayeva D. An aptasensor for the detection of Mycobacterium tuberculosis secreted immunogenic protein MPT64 in clinical samples towards tuberculosis detection. Sci Rep. 2019 Nov 7;9(1):16273. doi: 10.1038/s41598-019-52685-6
- Xie Y, Fan H, Lu W, Yang Q, Nurkesh A, Yeleussizov T, Maipas A, Lu J, Manarbek L, Chen Z, Benassi E. Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer. Oncogene. 2019 Apr;38(16):2967-2983. doi: 10.1038/s41388-018-0608-2
- Ranganathan S, Gribskov M, Nakai K, Schönbach C (Editors-in-Chief). Encyclopedia of Bioinformatics and Computational Biology (The A to Z of Bioinformatics). Volume 1-3, 1st Edition. pp. 1-3284, Elsevier, 2019. ISBN (ebook): 978-0-128-114322; August 31, 2018; ISBN (Print): ISBN 978-0-128-114148. January 1, 2019.
- Sun X, Shi Y, Akahoshi T, Fujiwara M, Gatanaga H, Schönbach C, Kuse N, Appay V, Gao GF, Oka S, Takiguchi M. Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation. Cell Rep. 2016 Jun 7;15(10):2279-2291. doi: 10.1016/j.celrep.2016.05.017.
- Sayyar B, Dodd M, Marquez-Curtis L, Janowska-Wieczorek A, Hortelano G. Fibronectin-Alginate microcapsules improve cell viability and protein secretion of encapsulated Factor IX-engineered human mesenchymal stromal cells. Artif Cells Nanomed Biotechnol. 2015;43(5):318-27. doi.org/10.3109/21691401.2014.885446
Publications
2021
- Zhadyra Mustafa, Anuar Zhanapiya, Hubert Kalbacher, and Timo Burster. Neutrophil elastase and protein-ase 3 cleavage sites are adjacent to the polybasic sequence within the proteolytic sensitive activation loop of the SARS-CoV-2 spike protein. 2021. ACS Omega. IF: 2.87
- Patricia Kattner, Katharina Zeiler, Verena J. Herbener, Katia La Ferla-Brühl, Rebecca Kassubek, Michael Grunert, Timo Burster, Oliver Brühl, Anna Sarah Weber, Hannah Strobel, Georg Karpel-Massler, Sibylle Ott, Alexa Hagedorn, Daniel Tews, Ansgar Schulz, Vikas Prasad, Markus D. Siegelin, Lisa Nonnenmacher, Pamela Fischer-Posovszky, Marc-Eric Halatsch, Klaus-Michael Debatin, Mike-Andrew Westhoff. What animal cancers teach us about human biology. 2021. Theranostics. Review. IF: 8.579
- Timo Burster, Fabian Gärtner, Uwe Knippschild, Anuar Zhanapiya. Activity-based probes to utilize the proteolytic activity of cathepsin G in biological samples. 2021. Feb. Frontiers in Chemistry. Invited Review. IF: 3.693.5.
- Fabian Gärtner, Uwe Knippschild, and Timo Burster. Application of an activity-based probe to deter-mine proteolytic activity of cell surface cathepsin G by mass cytometry data acquisition. ACS Omega. 2020. Oct 19;5(43):28233-28238. IF: 2.87
- Pengfei Xu; Fabian Gärtner; Adrian Gihring; Congxing Liu; Timo Burster; Martin Wabitsch; Uwe Knipp-schild; Stephan Paschke. Influence of obesity on remodeling of lung tissue and organization of extracellular matrix after blunt thorax trauma. Respiratory Research. 2020. Sep 17;21(1):238. IF: 3.89
- Timo Burster, Fabian Gärtner, Christiane Bulach, Anuar Zhanapiya, Adrian Gihring, and Uwe Knippschild. Regulation of MHC I molecules in glioblastoma cells and the sensitizing of NK cells. 2021. Pharmaceuticals. Invited Review. IF: 4.286
- Herbener, Goreth, Pruss, Burster, Bandemer, Baisch, Fitzel, Siegelin, Karpel-Massler, Debatin, Strobel, Westhoff. Considering the experimental use of Temozolomide in Glioblastoma research. Biomedicines. 2020. Jun 4;8(6):E151. Invited Review. IF: 4.717
- Burster, Knippschild, Molnar, and Zhanapiya. Cathepsin G and its role in modulating levels of MHC class I molecules. Archivum Immunologiae et Therapiae Experimentalis (AITE). 2020. Aug 19;68(4):25. Invited Review. IF: 2.85