The research work from the Department of Chemistry has been highlighted as a SynStory in a Thieme group journal SYNFORM
Some great news from the Chemistry Department!
The research work from the Department of Chemistry has been highlighted as a SynStory in a Thieme group journal SYNFORM.
SYNFORM complements the information provided by the Thieme Chemistry E-Journals. It serves the international chemistry community by publishing timely information about: new scientific advances in organic chemistry and related fields of research,
facts and people from the world of chemical sciences, highlights from international chemistry conferences.
SynStories feature new scientific advances, as reported in exciting recent papers in the field of organic chemistry, accompanied by the author’s personal views.
About the research
The development of new transformations allowing for selective synthesis of amines from readily accessible precursors continuously attracts significant attention from the synthetic chemistry community, since amines play an indispensable role as building blocks for the synthesis of many natural products, biologically active molecules, pharmaceutical compounds, agrochemicals, etc. In this regard, catalytic reduction of readily available simple feedstock molecules, such as nitriles, to amines using abundant first-row transition-metal catalysts represents an attractive alternative to conventional wasteful stoichiometric reduction methods and catalytic reductions with precious metal catalysts. However, examples of such base metal catalytic systems for efficient and selective room-temperature reduction of nitriles to amines are still scarce and generally require rather sophisticated ligands. Corresponding authors, Andrey Khalimon (PI of the project) and his collaborator Dr. Davit Hayrapetyan (a Postdoctoral Fellow at the Department of Chemistry) are interested in the development of economical and readily available abundant transition-metal pre-catalysts for the reduction of challenging unsaturated molecules and the application of such transformations in the synthesis of more complex organic molecules.
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