Laboratory for Cell Growth Regulation

Laboratory for Cell Growth Regulation

Laboratory for Cell Growth Regulation

Group for studying mechanism of eukaryotic transcriptional regulation in health and disease

Research Summary

Our group studies the mechanism of eukaryotic transcriptional regulation by understanding the function and action of transcription factors namely nuclear receptors. Nuclear receptors are zinc finger containing proteins targeting specific genes connected to nearly all biological processes in human such as development, energy homeostasis and metabolism. Their control is linked to recognition of small lipophilic compounds, ligands, that serve as signaling switches to activate or repress specific target genes. The dysregulation of nuclear receptor-directed transcription has functional consequences that lead to various maladies such as cancer or metabolic diseases. The deep understanding of molecular action of these proteins may provide new remedies for many disorders.

We aim to test well established and identify new ligands as potential drug candidates that can be used to target metabolic diseases and cancer via modulation of nuclear receptor signaling, to understand their mechanism of action in healthy and disease states to use this knowledge for early diagnostics or prevention of disease development.

Ferdinand Molnar                                E-mail: ferdinand.molnar@nu.edu.kz

 

Publications

Recent publications

Research articles

  1. Touloupi K, Küblbeck J, Magklara A, Molnár F, Reinisalo M, Konstandi M, Honkakoski P, Pappas P. The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression. Mol Pharmacol 2019 Nov; 96(5):655-663. doi: 10.1124/mol.119.117424
  2. Prantner V, Cinnamon Y, Küblbeck J, Molnár F, Honkakoski P. Characterization of a novel functional variant in nuclear receptor CAR (NR1I3). Nucl Receptor Res. 2018 vol. 5 doi: 10.32527/2018/101386

Reviews

  1. Maestro MA, Molnár F, Carlberg C. Vitamin D and its synthetic analogs. J Med Chem. 2019 Aug 8;62(15):6854-6875. doi: 10.1021/acs.jmedchem.9b00208

Books and Book Chapters

  1. Carlberg C, Molnár F. Human Epigenetics: How Science Works. (2019) 1st ed. Springer Nature pp. 1-153 (ISBN 978-981-10-7614-8)https://www.springer.com/gp/book/9783030229061
  2. Carlberg C, Molnár F. Human epigenomics. (2018) 1st ed. Springer Nature pp. 1-243 (ISBN 978-981-10-7613-8) http://www.springer.com/us/book/9789811076138

All publications

Pubmed [full author name search]

Google Scholar

 

 

Lab Members

Principal investigator

Ferdinand Molnár, Associate Professor, Scopus ID

Core Members

Zhalgas Serimbetov, Post-doctoral researcher, Scopus ID,

Karina Pats, visiting researcher/Ph.D. Student (ITMO university),

Aigerim Bizhanova, Ph.D Student

Pavel Li, Ph.D Student, Ph.D Student

Zhadyra Onzharova, Ph.D Student

Aiym Meiranbekova, M.Sc. Student

Aidana Tamshybay, M.Sc. Student

Zhazira Zhumabekova, NUZYP Student

Undergraduate Trainees

Azhar Mauletkan

Fatima Fazyl

Ex-lab Members

-

 

Contact Information

E-mail: ferdinand.molnar@nu.edu.kz

Related Links, Events, and News 

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