This collaborative research by Dr. Ahmed Elkamhawy from Nazarbayev University (NU), alongside a network of scientists from South Korea, Egypt, and Italy, highlights the discovery of new organic small molecules (chalcones) as potent inhibitors of human carbonic anhydrase (hCA) enzymes. These enzymes play crucial roles in various diseases such as glaucoma, obesity, and cancer. Among the newly synthesized compounds, one demonstrated particularly high effectiveness and selectivity against the hCA II isoform. This innovation could pave the way for novel therapeutic approaches targeting hCA-related diseases.
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To read the full paper, click this link.